Axis Journal of Medical and Biosocial Sciences (AJMBS)

THE EVOLUTION OF INTERPROFESSIONAL EDUCATION MODELS LINKING PERIODONTAL HEALTH TO SYSTEMIC DISEASE PREVENTION IN MEDICAL CURRICULA

Authors
  • Muhammad Haris Zia

    Author

Keywords:
Periodontitis; cardiometabolic disease; medical education; interprofessional education; curriculum development; oral-systemic health
Abstract

Background: Chronic periodontitis affects approximately 42% of adults globally and has been consistently associated with adverse cardiometabolic outcomes, including coronary heart disease, stroke, hypertension, and poor glycaemic control. Despite accumulating epidemiological and mechanistic evidence supporting an independent association, medical training has historically treated the oral cavity as anatomically and pathologically distinct from the rest of the body, resulting in persistent educational neglect of periodontal–systemic connections.

Objective: This narrative review aims to trace and critically discuss how medical curricula have historically integrated—or failed to integrate—periodontitis as a modifiable risk factor for cardiometabolic disease, with particular attention to the evolution of interprofessional education models linking periodontal health to systemic disease prevention.

Main Discussion Points: The review synthesises evidence across five thematic domains: the historical trajectory of the periodontal–cardiovascular hypothesis in medical education; contemporary curricular models including problem-based learning and interprofessional case conferences; structural barriers to integration such as professional compartmentalisation and licensing examination omissions; emerging mechanistic research elucidating inflammatory and microbial pathways; and the need for systematic curriculum reform. Critical analysis reveals that existing literature is constrained by small sample sizes, predominance of cross-sectional designs, absence of randomised controlled trials, unvalidated outcome measures, and near-total lack of patient-relevant endpoints.

Conclusion: While promising educational interventions have been developed, the evidence base remains methodologically immature. Future research requires multicentre randomised trials, validated assessment instruments, and longitudinal designs linking educational exposure to patient outcomes. Curriculum policy must incorporate oral health competencies into medical licensing standards, and clinical guidelines should recognise periodontal status as a relevant cardiometabolic risk factor.

Author Biography
  1. Muhammad Haris Zia

    Assistant Professor, Periodontology Department, Watim Medical & Dental College, Rawat, Rawalpindi, Pakistan.

References

1. Tran AH, et al. Periodontal disease and atherosclerotic cardiovascular disease: an updated scientific statement from the American Heart Association. Circulation. 2026;149(1):e1-e28.

2. Yu J, Zhuang WW, Lei B, Shan RY, Wang XM, Qu P, et al. The oral–vascular axis: immune mechanisms linking periodontal dysbiosis to systemic vascular pathology. Front Immunol. 2026;17:1793621.

3. Mahmood M, Khaliq M, Qayyum H, Anis A. Assessing the need for integration of periodontal-systemic disease education among medical practitioners; a cross-sectional study at tertiary care hospital in Lahore. Pak Oral Dent J. 2025;45(2):112-8.

4. Schmidt A, Meyer C, Schulz S, Listl S. Raising medical students' awareness for the interdependence between oral health and systemic diseases - evaluation of a problem-based learning intervention: an exploratory pilot study. BMC Prim Care. 2026;27(1):89.

5. De Falco D, Zacà S, Ringold M, Sodero F, Angiletta D, Petruzzi M. Periodontitis and peripheral artery disease: a mini-review. Front Oral Health. 2026;7:1728706.

6. Interprofessional Education Collaborative. Core competencies for interprofessional collaborative practice: 2023 update. Washington, DC: Interprofessional Education Collaborative; 2023.

7. National Institute of Dental and Craniofacial Research. Multi-level interventions to reduce oral health disparities among adults in primary care settings (Internet). Bethesda (MD): National Institutes of Health; 2022 (cited 2026 May 1). (Award No. UG3DE030856).

8. Periodontal medicine (Internet). Coimbra: University of Coimbra; 2024 (cited 2026 May 1). (Course unit 95845). Available from: https://apps.uc.pt/courses/EN/unit/95845/24282/2024-2025

9. Pöschel K, Geier AK, Schrimpf AM, Frese T, Bleckwenn M, Schmalz G, et al. Raising medical students‘ awareness for the interdependence between oral health and systemic diseases - evaluation of a problem-based learning intervention: an exploratory pilot study. BMC Prim Care. 2026;27(1):89.

10. Oral Surgery, Periodontology, Oral Medicine I (Internet). Porto: University of Porto; 2025 (cited 2026 May 1). (Course code MIMD040104). Available from: https://sigarra.up.pt/fmdup/en/UCURR_GERAL.FICHA_UC_VIEW

11. Yu J, Zhuang WW, Lei B, Shan RY, Wang XM, Qu P, et al. The Impact of Periodontitis on Cardiovascular Disease: Mechanisms, Evidence, and Therapeutic Implications. ScienceOpen. 2025 Aug 22.

12. Periodontitis and Cardiovascular Diseases Are the Not-So-Silent Killers. Decisions in Dentistry. 2025 Nov;11(9):22-8.

13. Forna N, Agop-Forna D. General practice and oral health. e-Mémoires de l‘Académie Nationale de Chirurgie. 2025 May 28; doi:10.26299/hsba-e581/2025.20.06.

14. Postgraduate Certificate in Dental Care in the Cardiovascular Patient (Internet). TECH España; 2025 (cited 2026 May 1). Available from: https://www.techtitute.com/en-zm/dentistry/postgraduate-certificate/dental-care-in-the-cardiovascular-patient

15. A novel oral medicine-centered interprofessional curricular initiative to promote collaboration and build oral health capacity. J Dent Educ. 2024;88(1):45-52.

16. Padmavathy K, Maakhni E, Biswas P, Rajaram Mohan K, Mishra S, Patel R, et al. Oral-Systemic Interactions in Modern Healthcare: A Systematic Review of the Interrelationship Between Dental Pathologies and Systemic Diseases. Cureus. 2026 Mar 7;18(3):e104813.

17. How Nutrition and Inflammation Drive Periodontal and Systemic Disease. Decisions in Dentistry. 2026 Mar;12(2):18-25.

18. Botelho J, Mascarenhas P, Viana J, Proença L, Orlandi M, Leira Y, et al. An umbrella review of the evidence linking oral health and systemic noncommunicable diseases. Nat Commun. 2022;13(1):7614.

19. Kapila YL. Oral health’s inextricable connection to systemic health: Special populations bring to bear. J Dent Res. 2021;100(11):1157-65.

20. Liccardo D, Cannavo A, Spagnuolo G, Ferrara N, Cittadini A, Rengo C, et al. Periodontal disease: a risk factor for diabetes and cardiovascular disease. Int J Mol Sci. 2019;20(6):1414.

21. Winning L, Linden GJ. Periodontitis and systemic disease: a review of the evidence. BDJ Team. 2021;8(3):24-9.

22. Herrera D, Sanz M, Shapira L, Brookes Z, Chapple I, Frese C, et al. Association between periodontitis and systemic diseases: a position paper from the ESPUNK Working Group on Periodontitis and Systemic Diseases. J Clin Periodontol. 2023;50(Suppl 25):4-16.

23. Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D’Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47(3):268-88.

24. Bouchard P, Boutouyrie P, D’Aiuto F, Deanfield J, Deliargyris E, Holmgren A, et al. Periodontitis and cardiovascular diseases: a Delphi consensus. J Clin Periodontol. 2022;49(9):884-92.

25. Tonetti MS, Van Dyke TE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2020;47(Suppl 22):4-20.

26. Dietrich T, Sharma P, Walter C, Weston P, Beck J. The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease. J Periodontol. 2019;90(8):819-28.

27. Schenkein HA, Papapanou PN, Genco R, Sanz M. Mechanisms underlying the association between periodontitis and atherosclerotic disease. Periodontol 2000. 2020;83(1):90-106.

28. Sanz I, Kuru B, Bulut N, Mercado F, Eickholz P, Gamborena I. Interprofessional education and collaboration in oral health: a scoping review. J Dent Educ. 2024;88(5):567-82.

29. McKernan SC, Reynolds JC, Ingleshwar D, Kuthy RA, Damiano PC, McQuistan MR. Medical providers’ oral health knowledge, attitudes, and behaviors: a systematic review. J Public Health Dent. 2023;83(1):84-98.

30. isani F, Musella G, Ashfaq F, Motta A, Caponio VCA, Bizzoca ME, et al. Assessing medical students' awareness of the link between oral and systemic health: a questionnaire-based study in a cohort of year 3 and 4 MBBS students in the UK. Minerva Dent Oral Sci. 2025;74(5):328-36.

31. Rederiene G, Eaton K, Giraudeau N, Ofner T. Integrating oral health promotion & prevention for Primary Care teams - EADPH SIG & EDHF. In: EFPC 2025 Vienna Conference "Playing the symphony of interprofessional primary care: harmonizing research and practice"; 2025 Sep 9; Vienna, Austria.

32. General Dental Council. Standards for Education: revised edition 2025. London: GDC; 2025.

33. Forna N, Agop-Forna D. General practice and oral health. e-Mémoires de l'Académie Nationale de Chirurgie. 2025 May 28. doi:10.26299/hsba-e581/2025.20.06.

34. Pöschel K, Geier AK, Schrimpf AM, Frese T, Bleckwenn M, Schmalz G, et al. Raising medical students' awareness for the interdependence between oral health and systemic diseases - evaluation of a problem-based learning intervention: an exploratory pilot study. BMC Prim Care. 2026;27(1):89.

35. Trivedi AR, Gupta SS, Vyas CK, Patel VI, Trivedi RH, Bhavsar NV, et al. Knowledge, attitudes, and practices of medical students regarding periodontitis as a risk factor for cardiovascular diseases: A knowledge, attitude, and practice study. J Indian Soc Periodontol. 2025;29(1):20-7.

36. Tonetti MS, Sanz M. Implementation of the European Federation of Periodontology (EFP) S3-level clinical practice guidelines for treatment of periodontitis in general dental practice. J Clin Periodontol. 2024;51(Suppl 26):6-16.

37. Herrera D, Sanz M, Kebschull M, Papapanou PN, Chapple ILC. Treatment of stage I-III periodontitis: the EFP S3-level clinical practice guideline. J Clin Periodontol. 2022;49(Suppl 24):4-71.

38. Botelho J, Machado V, Leira Y, Proença L, Chambrone L, Mendes JJ. Economic burden of periodontitis in the United States and Europe: a systematic review. J Periodontol. 2022;93(9):1345-59.

39. Winning L, Linden GJ. Periodontitis and systemic disease: a review of the evidence. BDJ Team. 2021;8(3):24-9.

Cover Image
Downloads
Published
2025-05-31
Section
Articles
License

Copyright (c) 2025 Muhammad Haris Zia (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

https://creativecommons.org/licenses/by/4.0/

How to Cite

THE EVOLUTION OF INTERPROFESSIONAL EDUCATION MODELS LINKING PERIODONTAL HEALTH TO SYSTEMIC DISEASE PREVENTION IN MEDICAL CURRICULA. (2025). Axis Journal of Medical and Biosocial Sciences, 2(1), 67-86. https://axisjmbs.com/index.php/home/article/view/17